Towards live imaging in cancer therapy
GENOA, Italy, April 19, 2021 /PRNewswire/ — ASG Superconductors with Helmholtz-Zentrum Dresden-Rossendorf (HZDR) will build the world’s first prototype that tracks moving tumors with magnetic resonance imaging (MRI) in real time during proton therapy, combining a rotating open MRI device for the LINAC-MR system Alberta Health Services, with an actively scanned clinical-akin proton beam at OncoRay, the Dresden-based National Center for Radiation Research in Oncology. The rotating MRI device is produced by ASG Superconductors, using the MROpen Evo technology-based helium-free superconducting MgB2 magnet. Real-time MRI would make it possible to synchronize the proton beam to tumor motion during radiation dose delivery. So far, this has been impossible and therefore was a limiting factor for treating moving tumors with this promising cancer therapy.
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Proton therapy is an emerging radiation technology to irradiate tumors while sparing the surrounding tissue better than conventional X-ray-based radiation due to the finite penetration depth of the protons. However, the effectiveness of proton therapy is limited by tumor motion, anatomical changes during therapy and set-up inaccuracies in patient positioning.
With the new MRI device and its real-time, high-contrast imaging capabilities for organs in the chest, abdomen and pelvis, Aswin Hoffmann from HZDR and his team now intend to build a first prototype which might be used clinically at some stage: "What is special about this MRI scanner is that it can be rotated around the patient relative to the beam, allowing us to study dosimetric and biological beam effects for MRI magnetic fields both perpendicular and parallel to the proton beam."
ASG Superconductors is now producing a mid-field-strength open 0.5 Tesla MRI device, which is specifically adapted to the requirements of real-time MRI-guided radiation therapy by the Alberta Health Services LINAC-MR group and its spin-off company MagnetTx Oncology Solutions. MagnetTx Oncology Solutions is developing the gantry that is required to rotate the MRI scanner as well as the image processing methods for automatically tracking the tumor in real time. The design and manufacture of the entire 30-ton device is currently in full swing. In summer 2022, the team plans to incorporate it in the actively scanned, clinical-akin experimental proton beamline at the OncoRay facility.
"It is very exciting for ASG Superconductors to be part of this project in collaboration with HZDR and MagnetTx," says Marco Belardinelli ASG Paramed MRI Unit Director and adds, "seeing our MRI and MgB2 superconducting technology used as a key component in new and innovative applications such as this one, which will ultimately benefit the patients and the medical community, makes us proud and even more confident we are moving in the right direction."
"Our partnership with HZDR and ASG has been extremely positive," says Mike Cogswell, MagnetTx President and CEO. "We look forward to continuing to work together to improve the cancer treatment industry."
"Thanks to this collaboration between HZDR and international industrial partners, we are a big step closer to our goal of bringing significant innovation to the field, especially to real-time image-guided proton therapy," says Hoffmann.
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